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香港科技大學2006-2007年報
研究與發展
Research & Development
薛紅教授
Prof Hong Xue
生物化學系副教授薛紅（中）及其研究小組，
在精神分裂症的研究領域上，取得研究突破。
她們發現與精神分裂症有關的基因變異，是與
「正面選擇」有關。若人體內被正面選擇的基因
模式較少，患上精神分裂症的機會將較高。該
項發現首次證明「正面選擇」與精神病相關基因
之間的聯繫。
Associate Prof Hong Xue (center), Department
of Biochemistry, and her research group
achieved a breakthrough in schizophrenia
studies. They found that variations in the schizophrenia-related gene are related to positive selection and
that those with the less mutated form may be more susceptible to the condition. The discovery is the first
to show that positive selection is associated with genes related to mental disorders.
數學系副教授陳北方完成符號圖不可約積分流（irreducible integral flows）及不可約積
分對（irreducible integral tensions）的分類，並對正整數中Tutte多項式作出闡釋。
Associate Prof Beifeng Chen, Department of Mathematics, has obtained the classification
of irreducible integral flows and irreducible integral tensions for signed graphs. He has
also found an interpretation for the Tutte polynomials at positive integers.
陳北方教授
Prof Beifeng
Chen
葉玉如教授
Prof Nancy Yuk-Yu Ip
生物化學系教授葉玉如（前排左）的科研成果，詳細
闡明突觸（神經細胞之間的連接點）的運作機制，以
及對學習和記憶形成的作用。研究小組揭示五型細胞
周期蛋白依賴型激酶（Cdk5），具有調節酪氨酸激酶
受體訊號傳遞和功能的作用，因而可進一步調控突觸
的發育。
Prof Nancy Yuk-Yu Ip (front row on left),
Department of Biochemistry, led research with
findings that have important implications in understanding the precise mechanisms by which synapse — the
connections between neurons — are fine-tuned to facilitate learning and memory. Her team unraveled the
essential role of cyclin-dependent kinase 5 in the regulation of synapse development through modulating
receptor tyrosine kinase signaling and functions.
科研亮點
科大的研究人員今年在各專業領域，取得纍纍
成果：
RESEARCH HIGHLIGHTS
HKUST researchers continued during the year to make substantial
contributions at the forefront of their disciplines.
